一、基本信息
刘梦元,博士,教授,硕士研究生导师
办公电话:027-88661237-8035
电子邮件:liumengy(AT)tom.com
社会兼职:湖北省生物化学与分子生物学学会会员
研究领域:抗体工程药物、基因工程药物
二、教育背景
1993.09–1996.07 湖北中医药大学医学检验系,学士
1999.09–2002.07 华中农业大学动物科技学院,农学硕士学位
2002.09–2005.07 中国协和医科大学中国医学科学院,医学博士
三、工作经历
2005-今,bwin国际讲师、副教授、教授
四、科研项目
1. 国家自然科学基金(30973669/H3004):新型靶向双功能抗体及其对类风湿关节炎的治疗,2010.01–2012.12,主持人
2. 国家自然科学基金(30972769/H1005):补体调节蛋白质C1抑制物的新功能研究,2010.01–2012.12,参与
3. 湖北省教育厅优秀中青科技计划项目(Q20081007):融合人血清白蛋白IL-1ra的构建及初步生物学活性分析,2008.01–2009.12,主持
五、代表著作(#共同第一作者,*通讯作者)
1. Liu M*,Huang Y, Hu L, Liu G, Hu X, Liu D, Yang X. (2012) Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion. BMC Biotechnology 12, 68.
2. Liu M, Wang X, Yin C, Zhang Z, Lin Q, Zhen Y, Huang H*. (2010) Targeting TNF-α with a tetravalent miniantibody TNF-TeAb. Biochemical Journal 406, 237–246.
3. Liu M, Wang X, Yin C, Zhang Z, Lin Q, Zhen Y, Huang H. (2006) One-step on column purification and refolding of a single chain variable fragment (scFv) antibody against tumor necrosis factor α. Biotechnology and Applied Biochemistry 43, 137–145.
4. Liu M, Wang X, Yin C, Zhang Z, Lin Q, Zhen Y, Huang H. (2008) A novel bivalent single chain Fv fragment inhibits tumor necrosis factor alpha action. Biotechnology and Applied Biochemistry 50, 173–179.
5. Cheng ZD, Liu M, Chen G, Zhang HM, Qin GJ, Liang G, Liu DX. (2008) Anti-vascular permeability of the cleaved reactive center loop within the carboxyl-terminal domain of C1 inhibitor. Molecular Immunology 45, 1743–1751.
6. Liu L, Qin XJ, Liu M, Zhang HM, Cheng ZD, and Liu D*. (2010) Silencing of C5a receptor gene with siRNA for protection from Gram-negative bacterial lipopolysaccharide-induced vascular permeability. Molecular Immunology 47, 1325–1333.
7. Hua D, Liu M, Cheng ZD, Qin XJ, Zhang HM, Chen Y, Qin GJ, Liang G, Li JN, Han XF, and Liu D*. (2009). Small interfering RNA-directed targeting of Toll-like receptor 4 inhibit human prostate cancer cell invasion, survival, and tumorigenicity. Molecular Immunology 46, 2876–2884.
8. 黄毅、胡磊、杨燕群、胡雪平、甄永苏、刘梦元*,IL-1Ra-HSA融合蛋白的构建、生物学活性和药动学分析。药学学报,2012,47, 1210–1218.