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一、基本信息
刘莉,博士,教授,博士生导师
电子邮箱:liuli2020(AT)hubu.edu.cn
学术兼职:担任New Phytologist, Plant Biotechnology Journal, Plant Molecular Biology, Environmental and Experimental Botany, Acta Physiologiae Plantarum等多个SCI刊物审稿人。担任国家人才项目通信评审专家,教育部学位中心通讯评议专家。2012年入选国际光合协会(International Society of Photosynthesis Research)会员,2015年入选云南省植物学会会员,2017年入选中国细胞生物学学会会员,2018年入选中国女科学家协会会员
二、教育背景
2003.09–2008.06 华中农业大学作物遗传改良国家重点实验室,博士
1999.09–2003.06 华中农业大学生命科学技术学院,学士
三、工作经历
2020.01至今 bwin国际,教授
2014.05–2019.12 中国科学院昆明植物研究所,研究员(入选2015年中科院人才计划)
2008.09–2014.04 美国加州大学戴维斯分校,博士后
四、科研项目
1. 2019 国家自然科学基金面上项目,主持
2. 2017 企业合作植物品种改良项目,主持
3. 2016 云南省“三区”项目,主持
4. 2015 国家自然科学基金面上项目,主持
5. 2015 中国科学院人才项目,主持
五、发表论文(#共同一作,*通讯作者)
1. Chen Z, Wang W, Pu X, Dong X, Gao B, Li P, Jia Y, Liu A, Liu L*. (2020) Comprehensive analysis of the Ppatg3 mutant reveals that autophagy plays important roles in gametophore senescence in Physcomitrella patens. BMC Plant Biology 20, 440.
2. Chen Z, Wang W, Dong X, Pu X, Gao B, Liu L*.(2020) Functional redundancy and divergence of β-carbonic anhydrases in Physcomitrella patens. Planta 252, 20.
3. Li P, Liu H, Yang H, Pu X, Li C, Huo H, Zhang C, Chu Z, Chang Y, Lin Y*, Liu L*. (2020) Translocation of drought-responsive proteins from the chloroplasts. Cells 9, 259.
4. Pu X, Yang L, Liu LN, Dong X, Chen S, Chen Z, Liu G, Jia Y, Yuan W, Liu L*. (2020) Genome-wide analysis of the MYB transcription factor superfamily in Physcomitrella patens. International Journal of Molecular Sciences 21, 975.
5. Pu X., Li P., Huo H., Dong X., Xie K., Yang H., Liu L*. (2019) A CRISPR/LbCas12a-based method for highly efficient multiplex gene editing in Physcomitrella patens. The Plant Journal 100, 863–872.
6. He J, Li P, Huo H, Liu L, Tang T, He M, Huang J, Liu L*. (2019) Heterologous expression of HpBHY and CrBKT enhance heat tolerance in Physcomitrella patens. Plant Diversity 41, 266–274.
7. Li P, Yang H, Wang L, Liu H, Huo H, Zhang C, Liu A, Zhu A, Hu J, Lin Y, Liu L*. (2019) Physiological and transcriptome analyses reveal short-term responses and formation of memory under drought stress in rice. Frontiers in Genetics 10, 55.
8. Guan Y#, Liu L#, Wang Q., Zhao J., Li P., Hu J, Yang Z, Running M, Sun H., Huang J. (2018) Gene refashioning through innovative shifting of reading frames in mosses. Nature Communications 9, 1555.
9. Li P, Yang H, Liu G, Ma W, Li C, Huo H, He J, Liu L*. (2018) PpSARK regulates moss senescence and salt tolerance through ABA related pathway. International Journal of Molecular Sciences19, 2609.
10. Yang H, Pu X, Wang L, Liu L*, Theg SM*. (2016) A new fluorescence-based method to monitor the pH in the thylakoid lumen using GFP variants. Biochemical and Biophysical Research Communications 10.10.
11. Tang T, Yu A, Li P, Yang H, Liu G, Liu L*. (2016) Sequence analysis of the Hsp70 family in moss and evaluation of their functions in abiotic stress responses. Scientific Reports 6, 33650.
12. Li X., Han H., Chen M., Yang W., Liu L., Li N., Ding X., Chu Z. (2016) Overexpression of OsDT11, which encodes a novel cystein erich peptide, enhances drought tolerance and increases ABA concentration in rice. Plant Molecular Biology 93, 21–34.
13. Yang W, Dong R, Liu L, Hu Z, Li J, Wang Y, Ding X, Chu Z. (2016) A novel mutant allele of SSI2 confers a better balance between disease resistance and plant growth inhibition on Arabidopsis thaliana. BMC Plant Biology 16, 208.
14. Liu L*, Xu W, Hu X, Liu H, Lin Y. (2016) W-box and G-box elements play important roles in early senescence of rice flag leaf. Scientific Reports 6, 20881.
15. Yu A, Li P, Tang T, Chen, Y, Liu L.* (2015) Roles of Hsp70s in stress responses of microorganisms, plants, and animals. Biomed Research International 2015, 51039.
16. Liu L, Shi L, McNeilage R, Theg S. (2014) ATP requirement for chloroplast protein import is set by the KM for ATP hydrolysis of stromal Hsp70. The Plant Cell 26, 1246–1255.
17. Zhou Y, Liu L, Lu L, Fan X, Huang W, Yuan M, Zhou F, Lin Y. (2014) Overexpression of OsSWEET5 in rice causes growth retardation and precocious senescence. PLoS One 9, e94210.
18. Zhou Y, Huang W, Liu L, Zhou F, Chen T, Lin Y. (2013) Identification and functional characterization of a rice NAC gene involved in the regulation of leaf senescence. BMC Plant Biology 13, 132.
19. Delatorre C#, Cohen Y#, Liu L#, Peleg Z, Blumwald E. (2012) The regulation of the SARK promoter activity by hormones and environmental signals. Plant Science 193, 39–47.
20. Liu L, Zhou Y, Szczerba M, Li X, Lin Y. (2010) Identification and application of a rice senescence-associated promoter. Plant Physiology 153, 1239-1249.
21. Wang L, Xie W, Chen Y, Tang W, Ye R, Liu L, Yang J, Lin Y, Xu C, Zhang QA. (2010) dynamic gene expression atlas of rice covering the whole life cycle using Affymetrix gene chip. The Plant Journal 61, 752-766.
22. Zhao L, Lu L, Zhou H, Liu L, Yu S, Lin Y. (2009) Identification of quantitative trait loci controlling rice mature seed culturability using contiguous introgression lines. Plant Cell Report 28, 247–256.
23. Ye R, Huang H, Yang Z, Chen T, Liu L, Lin Y. (2009) Development of insect-resistant transgenic rice with Cry1C*-free endosperm. Pest Management Science 65, 1015–1020.
24. Liu L., Zhou Y., Zhou G., Ye R., Zhao L., Li X., Lin Y. (2008) Identification of early senescence-associated genes in rice flag leaves. Plant Molecular Biology 67, 37–55.
五、专利
(一)已授权专利
1. 林拥军,刘莉。 水稻叶片衰老特异性启动子的鉴定及应用。专利号:CN200810048734.1。获得时间:2010年2月11日
2. 杨红,李萍,刘莉,鲁元学,章成君。一种皱叶青藓的快速繁殖方法。专利号:CN201610772729.X。获得时间:2018年6月5日
3. 杨红,李萍,刘莉,鲁元学,章成君。小立碗藓原丝体快速繁殖方法。专利号:CN 201610772610.2。获得时间:2018年9月25日
4. 刘莉,普晓俊,刘丽娜,李萍,杨红。CRISPR/Cas12a基因编辑系统在小立碗藓基因编辑中的应用。专利号:201910159312.X。获得时间:2019年11月6日
5. 刘莉,刘高京,杨红,李萍,徐伟,温从发,任昭杰。一种植物基因组差异甲基化区域的检测方法。专利号:201811561956.3。获得时间:2020年5月20日
6. 刘莉,和建芳,李萍,杨红。一种β-胡萝卜素酮化酶的人工合成突变体及其编码序列和应用。专利号:201810934991.9。获得时间:2020年8月20日
(二)审核中专利
1. 鲁元学,刘莉,杨红,李萍。一种苔藓石质墙体绿化方法。申请号:201710481390.2。申请时间:2017.6.22
2. 刘莉,李萍,杨红,马文章。一种对齿藓用于生态修复的方法。申请号:201710481072.6。申请时间:2017.6.22
3. 杨红,李萍,刘莉,鲁元学,章成君,关艳龙。一种小立碗藓原生质体的制备方法。 申请号:201610771350.7 申请时间:2016.8.30
4. 刘莉,李萍,马文章,杨红。PpMB1基因或PpMB1基因编码的蛋白质在提高植物耐脱水性中的应用。申请号:201810953647.4。申请时间:2018.8.22
5. 刘莉,李萍,杨红,章成君。苔藓 LRR1 基因在提高苔藓抗盐和抗衰老性能中的应用。 申请号:201810953634.7。申请时间:2018.8.22
6. 刘莉,杨红,李萍,徐伟,温从发,任昭杰。一种对质子浓度发生响应的荧光探针及其应用。申请号:201811562387.4。申请时间:2018.12.20
7. 刘莉,陈则希,李萍,杨红,李飞。小立碗藓ATG3 基因在植物衰老和耐盐胁迫中的应用。申请号:201901954892.2。申请时间:2019.2.19
8. 刘莉,李萍,杨红,袁文雅。一种叶绿体蛋白和ATPase酶活性突变体在提高植物抗逆性中的应用。申请号:201910151790.6。申请时间:2019.2.18
9. 刘莉,李青,普晓俊,李萍,温从发。一种明叶藓原丝体和配子体的快速繁殖方法。申请号:2019103210485。申请时间:2019.4.21
10. Li Liu, Xiaojun Pu, Lina Liu, Ping Li, Hong Yang. MULTIPLEX GENE EDITING IN PHYSCOMITRELLA PATENS via CRISPR/CAS12A SYSTEM。 申请号: 16/508712 。申请日:2019 年7月11日(美国专利)
六、受邀国际国内会议报告
1. 2020 Sept “苔藓高效多基因编辑系统建立和应用”。第七届全国植物生物技术与产业化大会暨植物基因编辑技术与应用专题研讨会, 扬州, 中国
2. 2019 April “Multiplex gene editing in Physcomitrella patents using CRISPR/Cpf1 and its application in analyzing HDS gene function”, 2019 Photosynthesis Conference, Xi’an, China(全国光合作用学术研讨会)
3. 2018 Oct “Regulation of plant drought memory”. The 16th National Congress Of Botany, Kunming, China(第十六届全国植物学大会)
4. 2018 Oct “ABA functions in moss drought memory formation” The 8th Annual Word Congress of Molecular & Cell Biology, Fukuoka, Japan(第八届国际分子细胞生物学大会)
5. 2018 Sept “Short-term response and the formation of memory under drought stress”. The 2nd Global conference on Plant Science and Molecular Biology, Rome, Italy(第2届国际植物科学和分子生物学大会)
6. 2017 Oct “Moss PA1 regulates dehydration tolerance”. 2017 National Congress Of Plant Biology, Chongqing, China (全国植物生物学大会)
7. 2015 Jul “What does Hsp70 do in moss chloroplasts”. The 8th Western Plant Biology and Resource Utilization Conference, Lasa, China (第八届西部植物生物学和资源利用会议)
8. 2014 Sept “ATP requirement for chloroplast protein import is set by the KM for ATP hydrolysis of stromal Hsp70”. The 17th Annual Moss International Conference, Beijing, China(第十七届国际苔藓大会)
9. 2011 Apr “A novel pH-sensitive GFP probe in chloroplast lumen”. The 7th Department of Plant Biology Retreat, California, USA(第七届加州大学植物生物学会议)