一、基本信息
杨勇,博士,教授,硕士研究生导师
办公电话:027-88661237-8051
电子邮件:yangyong(AT)hubu.edu.cn
研究领域:以果蝇为模式系统,构建精子运动的信号调控网络,揭示导致不孕不育症的分子机制
二、教育背景
2011至今,从事果蝇精子运动相关功能作用途径和调控机制以及果蝇分子遗传学研究,发表SCI论文一篇(Mol. Phylogen. Evol. top3,IF=3.9)
2007–2011(博士研究生学习阶段),在美国韦恩大学环境与健康研究所从事与果蝇精子运动相关功能基因的研究,系统的掌握了全套技术和分析方法,并以第一署名在Biology of Reproduction(top2,IF=3.5)(Yang et al, 2011) 和Molecular Biology of Cell (top3,IF=5.9) (Yang et al,2011)上发表了两篇有关果蝇精子运动的研究论文。
2001–2006(工作期间),从事果蝇分子遗传学研究,发表论文多篇;
1998–2001(硕士研究生学习阶段),在昆明动物研究所张亚平院士实验室从事果蝇遗传学研究,发表SCI论文一篇(IF=4.2)
1994–1998(本科学习阶段),在bwin国际细胞与遗传学实验室从事蜘蛛的遗传多样性研究,并发表论文一篇
四、科研项目
1. 果蝇防御素应用于家禽及家畜疾病防治与治疗的开发研究;武汉市晨光计划,2013–2016(6万元)
2. 男性不育症果蝇模型的建立及相关基因功能和作用途径解析(2012FFB00304)湖北省科技厅自然科学基金,2013–2015(3万元)
3. 3.果蝇极地适应性研究,美国康奈尔大学(国际合作),2013–2014(1万元)
4. RNA干扰技术在在模式生物果蝇中筛选新的功能基因(bwin国际自然基金Q20081013)2004–2007(0.5万元)
5. 在油菜中表达核盘菌重要功能基因hprna及其对油菜菌和病抗性影响的研究(国家自然基金项目30671334,参与)
6. 物质代谢流向与油菜种子含油量关系的研究(国家自然基金项目30771382,参与
7. 黑腹果蝇新突变型背甲着色图式的分子机制(国家自然基金项目30470970,第三主持人)
8. 取食抗、感水稻的褐飞虱中肠组织比较蛋白组学研究(国家自然基金项目31071679,第三主持人)
9. 果蝇剪接体内含子丢失及SOD基因的反转录转座与物种形成及适应辐射关系的研究(国家自然基金项目,30870292,第三主持人)
10. NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES, DK071073, USA, NIH.(2007.01–2009,负责实验室日常管理与技术指导,同时负责构建转基因果蝇品系;细胞培养;基因克隆、测序、功能分析;精子运动模式分析等具体试验工作)
五、代表著作(#共同第一作者,*通讯作者)
1. Yang Y, Hou ZC, Qian YH, Kang H, Zeng QT. (2012) Increasing the data size to accurately reconstruct the phylogenetic relationships between nine subgroups of the Drosophila melanogaster species group (Drosophilidae, Diptera). Molecular Phylogenetics and Evolution 30, 536–543.
2. Yang Y, Cochran DA, Gargano MD, King I, Samhat NK, Burger BP, Sabourin KR, Hou Y, Awata J, Parry DAD, Marshall WF, Witman GB, Lu X. (2011) Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50. Molecular Biology of the Cell 22, 976–87.
3. Yang Y, Lu X. (2011) Drosophila sperm motility in the reproductive tract. Biology of Reproduction 84, 1005–1015.
4. Yang Y, Zhang YP, Qian YH, Zeng QT. 2004. Phylogenetic relationships of Drosophila melanogaster species group deduced from spacer regions of histone gene H2a. Molecular Phylogenetics and Evolution 30, 336–343.
5. Zhan LL, Tian J, Liu C, Ke F, Yang Y, Li CX, Qian YH, Zeng QT.(2008) An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup and phylogenetic analysis. Journal of Heredity 99, 417–420.
6. Deng Q, Zeng Q, Qian Y, Li C, Yang Y. (2007). Research on The Karyotype and Evolution of Drosophila melanogaster Species Group. Jounal of Genetics and Genomics 34,196–213.
7. Yan X, Zeng Q, Yang Y, Qian Y. (2006) Molecular phylogenetic relationships of Drosophila immigrans species group based on H2a-H2b spacer and Cyt B sequences. Journal of Molecular Cell Biology. 39, 277–280.
8. Wang J, Yang Y, Zeng Q. (2006) Molecular evolution of intron in histone genes in Drosophila melanogaster species group. Journal of Hubei University. 28, 72–74, 90.
9. Li M, Chen J, Yang Y, Liu J, Peng Y, Liu FX. (2006) Phylogenetic analyses of the Neriene spiders (Araneae:Linyphiidae) based on partial mitochondrial COI DNA sequence. Acta Arachnologica Sinica 15, 14–18.
10. Zhang Q, Yang Y, Zeng QT. (2005) Clone and analysis of the conserve regions in histone H3 gene in Larinioides cornuta. Acta Arachnologica Sinica. 14, 95–99.
11. Mou SL, Zeng QT, Yang Y, Qian YH, Hu GA. (2005) Phylogeny of species group inferred from ND4L and ND4 genes. Zoological Research 26, 344–349.
12. Zhang CZ,Zeng QT,Qian YH,Yang Y. (2004) Phylogenetic relationships among several genera in Drosophilidae deduced from mitochondrial cytochrome b gene partial sequence. Journal of Hubei University (Natural Science Edition) 26, 344–349.
13. Xu SH, Zeng QT, Qian YH, Li ST, Yang Y. (2003) Random Amplified Polymorphic DNA(RAPD) Analysis of Drosophila simulans in the mainland of China. Acta Genetica Sinica. 30, 673–680.
14. Zhang J, Zeng QT, Xue XQ, Qian YH, Jin S, Yang Y. (2001) Studies of localization of black streak body gene in Drosophila melanogaster. Acta Genetica Sinica 28, 527–534.
15. Xue X, Zeng Q, Yang Y. (2000) An improved method for Drosophila salivary gland chromosome. Laboratory Research and Exploration 14.
16. Zeng QT, Yang Y, Yan B. (1999) Meiosis of Spider. Laboratory Research And Exploration 18, 54–56.