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一、基本信息
魏子贡,博士,bwin国际教授
电子邮件:weizigong(AT)163.com
研究领域:动物病毒毒力因子结构解析与分子药物设计,动物病原基因工程疫苗。
二、教育背景
2005.09–2010.07 华中农业大学动物医学院预防兽医学专业,博士
2001.09–2005.07 华中农业大学生命科学技术学院国家生命科学与技术人才培养基地专业,工学学士
三、工作经历
2015.05至今 bwin国际,副教授、教授
2010.09–2013.06 中山大学bwin国际,博士后
四、科研项目
1. 中国博士后基金(20110490971):CD44作为猪链球菌抗病育种候选基因的可行性初步研究,3万,主持
2. 国家自然科学基金青年基金项目(31402036):miRNAs介导CD44调控猪肺泡巨噬细胞粘附吞噬马链球菌兽疫亚种的作用机制,25万,主持
3. 湖北省自然科学基金(2014CFB344):miR-194b-3p介导CD44调控猪肺泡巨噬细胞粘附吞噬马链球菌兽疫亚种的分子机制,6万,主持
4. 武汉市“黄鹤英才计划”专项,规模化猪场猪链球菌病防控体系研究与示范,400万,主持人
5. 横向课题:悬浮培养提高圆环疫苗抗原浓度的技术开发,230万,主持
6. 横向课题:猪肺炎支原体低血清或无血清培养技术开发,50万,主持
7. 横向课题:规模化猪场猪蓝耳病防控技术体系研究,1000万,主持
8. 横向课题:规模化猪场猪蓝耳病监控与控制技术研究,500万,主持
9. 横向课题:一种治疗猪混合感染呼吸道疾病创新药物的研发,100万,主持
10. 横向课题:副猪嗜血杆菌亚单位疫苗研究,50万,主持
11. 横向课题:猪蓝耳病病毒复制抑制剂筛选与评价,500万,主持
12. 横向课题:一种减轻猪炎症反应的中草药饲料添加剂开发,300万,主持
13. 横向课题:猪蓝耳病病毒T细胞免疫增强剂开发,500万,主持
14. 横向课题:非洲猪瘟生物安全预警体系的开发,200万,主持
五、代表性论文:
1. Tang B, Liang H, Zhao P, Wei Z. (2017) Mir-194b-3p partially inhibits streptococcus equi subsp. zooepidemicus adherence to pk15 cells. Veterinary Microbiology 210, 38–42.
2. Liang H, Tang B, Zhao P, Deng M, Yan L, Zhai P, Wei ZG. (2018) Identification and characterization of a novel protective antigen, sec_205 of streptococcus equi ssp. zooepidemicus. Vaccine 36, 788–793.
3. Gao XJ, Tang B, Liang HH, Yi L, Wei ZG. (2019) Selenium deficiency inhibits micRNA-146a to promote ROS-induced inflammation via regulation of the MAPK pathway in the head kidney of carp. Fish & Shellfish Immunology 91, 284–292.
4. Tang B, Liang H, Gao X, Wei ZG. (2019) Identification of a surface protective antigen, map of streptococcus equi subspecies zooepidemicus. Research in Veterinary Science, 124, 387–392.
5. Gao X, Tang B, Liang H, Yi L, Wei Z. (2019) The protective effect of nigeglanine on dextran sulfate sodium-induced experimental colitis in mice and caco‐2 cells. Journal of Cellular Physiology 234, 23398–23408.
6. Wei Z, Fu Q, Chen Y, Cong P, Xiao S, Mo D, He Z, Liu X. (2012) The capsule of Streptococcus equi ssp. zooepidemicus is a target for attenuation in vaccine development. Vaccine 30, 4670–4675.
7. Wei Z, Fu Q, Liu X, Chen Y. (2012) Attenuated Streptococcus equi ssp. zooepidemicus as a bacterial vector for expression of porcine circovirus type 2 capsid protein. FEMS microbiology letters 332, 20–26.
8. Wei Z, Fu Q, Liu X, Xiao P, Lu Z, Chen Y. (2012) Identification of Streptococcus equi ssp. zooepidemicus surface associated proteins by enzymatic shaving. Veterinary microbiology 159, 519–525.
9. Wei Z, Li R, Zhang A, He H, Hua, Y., Xia J, Cai X, Chen H, Jin M. (2009) Characterization of Streptococcus suis isolates from the diseased pigs in China between 2003 and 2007. Veterinary microbiology 137, 196–201.
10. Wei Z, Fu Q, Chen Y, Li M, Cong P, Mo D. et al. (2013). Streptococcus equi ssp. zooepidemicus c5a peptidase, a putative invasin, induces protective immune response in mice. Research in Veterinary Science 95, 444–450.
11. Fu Q, Wei Z, Chen Y, Xiao P, Lu Z, Liu X. (2013) Identification of a surface protective antigen, CSP of Streptococcus equi ssp. zooepidemicus. Vaccine 31, 1400–1405.
12. Fu Q, Wei Z, Liu, X, Xiao P, Lu Z, Chen Y. (2013) Glyceraldehyde-3-phosphate dehydrogenase, an immunogenic Streptococcus equi ssp. zooepidemicus adhesion protein and protective antigen. Journal of Microbiology and Biotechnology 23, 579–585.