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一、基本信息
江正兵,博士、教授、博士生导师,省部共建生物催化与酶工程国家重点实验室副主任,入选教育部人才计划、湖北省人才计划,获湖北省杰出青年科学基金、创新群体资助
办公电话:027-88663882
电子邮件:zhbjiang(AT)hubu.edu.cn
研究领域:生物化工专业,主要关注分子酶工程、生物催化与转化、生物质资源综合利用等领域研究
二、教育背景
2004–2007 华东理工大学生物反应器工程国家重点实验室,生物化工/工学博士
1999–2002 bwin国际,生物化学与分子生物学/理学硕士
1993–1997 bwin国际,生物学/理学学士
三、工作经历
2007至今 bwin国际,副教授、教授
2014–2015 美国佐治亚州立大学,访问学者
1997–2004 bwin国际,实验师
四、近5年主持科研项目
1. 国家重点研发计划项目(2020YFA0908400):新蛋白质元件人工设计合成及应用,2020.11– 2025.10
2. 国家重点研发计划子课题(2019YFA0905001):天然途径生化反应的机制解析与新砌块设计,2020.01–2024.12
3. 湖北省重大科技创新计划子课题(2019ABA117):高效农业微生物菌剂及新型肥料研制,2019.01–2020.12
4. 武汉合缘绿色生物股份有限公司横向课题(201910702001019):生物质高效转化微生物菌剂技术开发,2019.10–2020.12
5. 湖北省自然科学基金创新群体(2018CFA019):生物酶协同效应在秸秆饲料化过程中的作用机制及应用研究,2018.01–2020.12
6. 中央引导地方科技发展专项(2018ZYYD-34):秦巴山区农作物秸秆综合利用及生态农业集成示范,2018.09–2020.08
7. 湖北省技术创新专项子课题(2018ABA096):基于高效微生物菌剂的土壤改良技术研发及产品研制,2018.01–2019.12
8. 武汉市科技局应用基础研究项目(2017020201010229):基于协同效应的全细胞酶制剂开发及应用研究,2017.01–2019.12
9. 湖北省技术创新专项子课题(2017ABA139):秸秆资源饲料化高效利用关键技术研发,2017.01–2018.12
五、发表主要论文(第一及通讯作者):
1. Hu P, Li H, Xiao W, Xie X, Yang, Duan L, Zhou S, Hu Y, Qiao Q, Ran Q, Jiang Z*. (2020) Effect of Rhodococcus sp. pretreatment on cellulose hydrolysis of corn stalk. Preparative Biochemistry & Biotechnology 5, 1–7.
2. Xiao W, Song H*, Li H, Xu Li X, Yang Y, Hu P, Zhou S, Hu Y, Xu X, Zhang Z, Jiang Z*. (2020) Effect of different biological surfactants on engineering Saccharomyces cerevisiae in simultaneous saccharification and fermentation of corncob. BioResources 15, 2512–2524.
3. Xiao W, Li H, Xia W, Yang Y, Hu P, Zhou S, Hu Y, Liu X, Dai Y, Jiang Z*. (2019) Co-expression of cellulase and xylanase genes in Sacchromyces cerevisiae toward enhanced bioethanol production from corn stover. Bioengineered 10, 513–521.
4. Li H, Wang C, Xiao W, Yang Y, Hu P, Dai Y, Jiang Z*. (2019) Dissecting the effect of polyethylene glycol on the enzymatic hydrolysis of diverse lignocellulose. International Journal of Biological Macromolecules 131, 676–681.
5. Zi–Lu Liu Z, Li H, Song H, Xiao W, Xia W, Liu X, Jiang Z*. (2018) Construction of a trifunctional cellulase and expression in Saccharomyces cerevisiae using a fusion protein. BMC Biotechnology 18, 43.
6. Song H, Yang Y, Liu D, Xu X, Xiao W, Liu Z, Xia W, Wang C, Yu X, Jiang Z*. (2017) Construction of recombinant Yarrowia lipolytica and its application in bio–transformation of lignocellulose. Bioengineered 17, 1–6.
7. Song H, Gao Y, Yang Y, Xiao W, Liu S, Xia W, Liu Z, Yi L, Jiang Z*. (2016) Synergistic effect of cellulase and xylanase during hydrolysis of natural lignocellulosic substrates. Bioresource Technology 219, 710–715.
8. Song H, Xiao W, Yang Y, Zhao Y, Gao Y, Liu S, Liu Z, Xia W, Li R, Li N, Jiang Z*. (2016) Improving the anti-oxidation of glucose oxidase with computer-aided structure optimization, Journal of Advances in Biotechnology 5, 736–740.
9. Song H, Liu S, Yuan Gao Y, Yang Y, Xiao W, Xia W, Liu Z, Li R, Ma X, Jiang Z*. (2016) Simultaneous saccharification and fermentation of corncobs with genetically modified Saccharomyces cerevisiae and characterization of their microstructure during hydrolysis. Bioengineered 7, 198–204.
10. Song H, Liu J, Liu Y, Leng H, Li X, Zhao Y, Yang X, Jiang Z*. (2014) Genetically modified Saccharomyces cerevisiae for one-step fermentation of bioalcohol using corncob as sole carbon source. Annals of Microbiology 64, 781–785.
11. Song H, Deng R, Jiang Z*. (2012) High efficient fermentation of natamycin with Streptomyces gilvosporeus HBJ591. 2, 65–69.
12. Song H, Zhou L, Zhang L, Gao B, Wei D, Shen Y, Wang R, Madzak C, Jiang Z*. (2011) Construction of a whole-cell catalyst displaying a fungal lipase for effective treatment of oily wastewaters. Journal of Molecular Catalysis B: Enzymatic 71, 166–170.
13. Yang X#, Jiang Z#, Song H, Jiang S, Madzak C, Ma LX. (2009) Cell-surface display of the active mannanase in Yarrowia lipolytica with a novel surface-display system. Biotechnology & Applied Biochemistry 54, 171–176.
14. Jiang Z, Gao B, Ren R, Tao X, Ma Y, Wei D. (2008) Efficient display of active lipase LipB52 with a Pichia pastoris cell surface display system and comparison with the LipB52 displayed on Saccharomyces cerevisiae cell surface. BMC Biotechnology 8, 4.
15. Jiang Z, Song H, Gupta N, Ma LX, Wu Z (2007) Cell surface display of functionally-active lipases from Yarrowia lipolytica in Pichia pastoris. Protein Expression and Purification 56, 35–39.
16. Jiang Z, Wang H, Ma Y, Wei D. (2006) Characterization of two novel lipase genes isolated directly from environmental sample. Applied Microbiology and Biotechnology 70, 327–332.
17. Song H, Jiang Z*, Ma L. (2006) Expression and purification of two lipases from Yarrowia lipolytica AS 2.1216. Protein Expression and Purification 47, 393–397.
18. Jiang Z, Zheng Y, Luo Y, Wang G, Wang H, Ma Y, Wei D. (2005) Cloning and expression of a novel lipase gene from Pseudomonas fluorescens B52. Molecular Biotechnology 31, 95–102.
六、授权/申请专利:
1. 纳他霉素高产菌株的选育及纳他霉素高效发酵提取纯化方法,专利号:ZL200810047019.6
2. 一种纳他霉素提取纯化方法,专利号:ZL200910222792.6
3. 一种提高葡萄糖氧化酶抗氧化性的方法,专利号:ZL201510428825.8
4. 使用工程化的解酯耶氏酵母生产高蛋白秸秆饲料的方法,专利号:ZL201610227696.
5. 一种利用天然纤维素为唯一碳源进行同步糖化发酵的方法,申请号:201510418255.4
6. 一种农作物秸秆酶解用复合酶及其工艺,申请号:201610152223.9
7. 木聚糖降解与木糖利用的酿酒酵母及混合发酵方法,申请号:201711122870.6
8. 一种多功能纤维素酶基因及其应用,申请号:201810807008.
9. 一种可降解木质纤维素的重组酿酒酵母菌株及其应用,申请号:201810806958.8
10. 一种酚类污染物降解菌及其应用,申请号:201910233030.X
11. 一种提高木质纤维素糖化效率的方法,申请号:201910910636.2
12. 一种秸秆混合发酵饲料及其生产方法,申请号:201910911060.1
七、获奖情况
1. 2010年,上海市科技进步奖一等奖:工业酶制剂的创制与产业化关键技术
2. 2011年,武汉市科技进步奖三等奖:纳他霉素大规模发酵过程优化及提取纯化技术.
3. 2016年,全国商业科技进步奖一等奖:植物源生物活性物质精提用酶制剂的研发与应用.
4. 2017年,湖北省科技进步奖二等奖:生物酶理性改造与高效发酵关键技术及应用.